CAD Design & Engineering Visualization
Project 1: Focused Blood-Brain-Barrier Drug Delivery
To address the lack of experimental platforms for studying consciousness in the brain, this project developed a novel system with applications including mitigating adverse effects of general anaesthesia.
We synthesised molecular complexes combining neuroactive agents with fluorescent markers through custom linking systems, exploring multiple iterations to optimise pharmacological properties. As these complexes are too large to naturally cross the blood-brain barrier, we employed focused ultrasound with microbubbles to transiently open the barrier.
The approach was validated through patch clamp electrophysiology in ex vivo rat brain slices, followed by in vivo delivery in zebrafish using microinjection and focused ultrasound, confirmed by fluorescence imaging. Results demonstrated the fundamental working principle, establishing a refined methodology for future consciousness research.
I utilised SOLIDWORKS throughout this project for both project visualisation as well as 3D printing parts we used to carry out experiments effectively.
Patch-Clamp Configuration
An animation illustrating the Patch-Clamp electrophoresis of a rat brain slice utilized by Koslov Lab at Imperial, featuring the ScientificaStar Micromanipulator, Olympus BX51W1 Microscope, and Scientifica SlicePlatform at a 1:1 scale reconstruction from measuring configuration by hand.
Zebrafish Larvae Nanoinjection
An animation depicting the Injection of zebrafish larvae using the Drummond Nanoject II Auto-Nanolitre Injector attached to its respective Micromanipulator Model MM33 Right-Handed Configuration at a 1:1 scale reconstruction from measuring apparatus by hand.
Focused Ultrasound Appartus
An animation showcasing the Focused Ultrasound Setup utilized by the Noninvasive Surgery and Biopsy Lab at Imperial. This setup includes a transducer (I8-0116-P, Olympus) that emits ultrasound waves, a light source to enhance the microscope's visual clarity (KL 2500, Schott), cage assembly rods and couplers (THORLABS), and a 1mm hydrophone to calibrate the transducer, ensuring precise sonication (Precision Acoustics). All components are modelled at 1:1 scale reconstruction from measuring apparatus by hand.
Modified Zebrafish Holder
I adjusted a holder for the Focused Ultrasound Setup to improve the experimental workflow. The modifications included:
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Two arms for stable level mounting.
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An open design to provide visual clarity and unobstructed ultrasound passage for sonication.
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A square cut-out on the inferior surface to allow light from the source to pass through.
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Markings to indicate the center of the cut-out from the observation angle.
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A shallow depression on the inferior surface for stable fastening and positioning of the zebrafish-embedded agarose block.
This model was printed with PLA using a Bambu Lab A1 printer.
Project 2 : Augmented Reality Learning Tool for Children with Cerebral Palsy
Designed and prototyped hardware for an augmented reality educational tool targeting children with severe cerebral palsy (GMFCS levels 4-5). Using SOLIDWORKS, I developed multiple design solutions including a wheelchair-mounted screen system with custom attachment mechanisms to accommodate varied wheelchair configurations and user positioning constraints.
Conducted systematic design evaluation across quantitative metrics: optical clarity, structural portability, mounting accessibility, and performance under variable lighting conditions. Through iterative CAD refinement and animation validation, I assessed biomechanical compatibility and user interaction requirements for motor-impaired populations.
The final design ended up utilising a stationary Pepper's Ghost optical system, selected for its superior image fidelity and seamless integration into classroom environments whilst minimising physical demands on users with limited gross motor function.
Exploded View of An Early Design Iteration
Project 3: Modular Tomato Planter with DNA Support Structure
I designed a stackable plant pot system on SOLIDWORKS featuring a double-helix DNA-inspired support frame. The modular design allows sections to be added as the tomato plant grows, with the helical structure providing vertical support for the climbing plant. The interlocking components connect like building blocks, enabling height adjustment throughout the growing season whilst maintaining structural stability.
Technical Drawing of Plant Pot Design
Side profile of assembled and unassembled Plant Pot Design
Animation of Assembly